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KMID : 0861020000150020069
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Korea Journal of Herbology
2000 Volume.15 No. 2 p.69 ~ p.77
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Effect of Betulae Platyphyllae Cortex on Free radical in Diabetic Rats induced by Streptozotocin
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Abstract
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Type I diabetes is caused by destruction of the pancreatic beta cells responsible for insulin-secretion. It can be induced by the drugs alloxan or streptozotocin (STZ). Both an increase in reaction oxygen free radical species and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes mellitus. Oxygen radicals scavengers are effective in preventing diagetes in animal models. Experiments were conducted by two system. The Sprague-Dawley rats were treated with STZ intravenous injection after oral administrated Betula´s extract and quercetin for a week, and were administrated them for a week. In vitro, Betula´s extracts and quercetin showed a tendency towards inhibition of free radical oxidation in all. In vivo, Betula´s extracts group exhibited suppression morphologic change in pancreatic islet compare quercetin group on light microscopy. The Betula´s extract significantly inhibited formation of MDA compared to the STZ-induced diabetic group in pancreas.They also significantly inhibited formation of Phosphatidylcholine hydroperoxide(PCOOH) compared to the STZ-induced diabetic group in pancreas and plasma, which considered defense against destruction in beta cells. The protection by Betula´s extracts may be due to scavenging of deleterious and highly reactive free radical which is generated by STZ. In streptozotocin-induced diabetic rats, the effect of Betula´s extract are greater than that of quercetin. Based on this result, we concluded that Betula´s extract has the ability to effectively suppress in vitro and in vivo oxidation, thereby providing additional evidence for their potential beneficial type I diabetes.
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